ANTIMITOTIC RHIZOXIN DERIVATIVES OF BURKHOLDERIA RHIZOXINA, METHOD FOR PRODUCING SAID DERIVATIVES AND USE THEREOF

摘要

The invention concerns novel secondary metabolites of the Burkholderia rhizoxina endosymbiont, a method for isolating said compounds from cultures of the bacteria and the use of said substances. The invention aims at providing novel rhixozin derivatives with antimitotic effect. Therefor, the following substances (1-4) are isolated, said substances exhibiting potent antifungal, cytotoxic and antiproliferative properties.