<p>Although preferred illustrative embodiments of the Apparatus and methods for endometrial biopsies, wherein an fapplicator is disposed on the distal end of an outer tube and an injection device is connected to the proximal end of the same tube. The applicator may- comprise one or more ridges on its outer surface that anchor the applicator to the cervical os and that cause the applicator to remain securely positioned and maintain the os in a dilated position during the entire procedure. A method for performing endometrial biopsies is also provided. The apparatus and methods according to the present invention are configured to minimize discomfort to the patient while facilitating the operation of a clinician.</p>