Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function

摘要

The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R₁ may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R₂ is hydrogen, lower alkyl, or substituted lower alkyl; and R₃, R₄ and R₅ are optionally non-interfering substituents as defined in the specification.