METHODS OF USING ZC1 AND ZC3 KINASE SUBSTRATE PHOSPHORYLATION AS BIOMARKERS

摘要

The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a mammal is responding to a compounds that modulates ZC1 or ZC3 kinase activity, and methods of predicting whether a mammal will respond therapeutically to a method of treating cancer by administering a modulator of ZC1 or ZC3 kinase.