摘要 |
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R<SUB>5 </SUB>is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R<SUB>18</SUB>, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R<SUB>3</SUB>. Substituent R<SUB>3 </SUB>is defined herein. |