BIOCONJUGATES COMPRISING SULFATED POLYSACCHARIDES AND THEIR USES
摘要
The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate group of said sulfated polysaccharide. The bioactive polypeptide can be a heparin-binding polypeptide or a positively-charged polypeptide and is preferably a peptide growth factor or a cytokine. The bioconjugates serve as delivery systems for sustained release of the bioactive polypeptides. Also provided are pharmaceutical compositions comprising the bioconjugates or comprising the sulfated polysaccharides.
申请公布号
WO2007043050(A2)
申请公布日期
2007.04.19
申请号
WO2006IL01178
申请日期
2006.10.15
申请人
BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY;COHEN, SMADAR;FREEMAN, INBAR