MODULATORS OF THE PURINERGIC SIGNALLING PATHWAY FOR TREATING SODIUM HOMEOSTATSIS, HYPERTENSION AND ALDOSTERONISM

摘要

The invention relates to agents and methods for preventing and/or alleviating a condition in an individual associated with abnormal sodium homeostasis wherein the compound is capable of modulating the activity of a component of the purinergic signalling pathway. In particular, the invention relates to agents and methods for preventing and/or alleviating a condition in an individual selected from the group comprising: primary aldosteronism; secondary aldosteronism; heightened sensitivity to aldosterone and/or essential hypertension.