发明名称 |
ANTI-MYOSTATIN ANTIBODIES |
摘要 |
<p>A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.</p> |
申请公布号 |
CA2624976(A1) |
申请公布日期 |
2007.04.19 |
申请号 |
CA20062624976 |
申请日期 |
2006.10.05 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
HAN, BOMIE;O'BRYAN (NEE TOBIAS), LINDA;KORYTKO, ANDREW;SMITH, ROSAMUND CAROL;MITCHELL, PAMELA JEAN;WANG, RONG |
分类号 |
C07K16/22;A61K39/395;A61P21/00 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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