发明名称 |
AMINOPYRIMIDINES AS KINASE MODULATORS |
摘要 |
<p>Abstract The invention is directed to aminopyrimidine compounds of Formula I: where R3, B, Z, r and R1 are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB . The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.</p> |
申请公布号 |
WO2006135719(A1) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2006US22411 |
申请日期 |
2006.06.07 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;GAUL, MICHAEL DAVID;XU, GUOZHANG;BAUMANN, CHRISTIAN, ANDREW |
发明人 |
GAUL, MICHAEL DAVID;XU, GUOZHANG;BAUMANN, CHRISTIAN, ANDREW |
分类号 |
A61K31/506;A61P35/00;C07D239/48;C07D401/12;C07D403/04 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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