ANTI-INFLAMMATORY AGENTS

摘要

The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(r-methylcyclohexylcarbonylamino)-caprolactam: wherein z is 1,2,3 or 4; A is -CO- or -SO2-; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, akylamino, alklylaminoalkyl, haloalkyl, aryl or substituted aryl; T<SUP>1</SUP> and T<SUP>2</SUP> together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T<SUP>1</SUP> and T<SUP>2</SUP> may be independently be substituted by a group R<SUP>1</SUP>, where R<SUP>1</SUP> is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R<SUP>1</SUP> is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.