PROCESS FOR SYNTHESIZING LABELLED COMPOUNDS

摘要

The main objectives of the invention are notably: the shrinkage of the process time because of the low half-life of [<SUP>18</SUP>F]FLT, as well as the increase of the yield, especially without HPLC purification which is a complex and a time consuming step. Other intended improvements are the reduction of the duration and the complexity of the synthesis and of the device. The purpose is to facilitate the methods of synthesis used by the Positron Emission Tomography (TEP) laboratories. The invention concerns a process for synthesizing labelled compounds with an isotopic element, comprising the steps of: a. preparing at least one labelling agent; b. labelling at least one precursor with the labelling agent, wherein the precursor is a protected substrate; c. possibly pre-purifying the labelled precursor; d. retaining the labelled precursor on at least one solid support; e. deprotecting the labelled precursor by hydrolysis so as to obtain the labelled compound, directly on at least one solid support which is contained in at least one column or cartridge; f. recovering the labelled compound by elution g. and purifying the eluate, wherein the labelled compound is 3'-deoxy-3'-[<SUP>18</SUP>F]fluorothymidine ([<SUP>18</SUP>F]FLT) wherein the deprotectionhydrolysis is carried out by means of at least one deprotectionhydrolysis is carried out by means of at least one deprotecting/hydrolyzing agent selected in the organic acids groups comprising e.g.: trifluoroacetic acid (TFA) and/or the purifying step (g) comprises transferring the eluate containing the labelled compound on at least one hydrophilic-lipophilic water-wettable reversed-phase sorbent for solid-phase extraction.