Mediators of epithelial adhesion and their role in cancer and skin disorders

摘要

Perp is shown to mediate stratified epithelial development in vivo. Perp localizes specifically to desmosomes, adhesion junctions important for tissue integrity. In some embodiments of the invention, detection of autoantibodies specific for perp find use in the diagnosis of pemphigus. In other embodiments, agent that upregulate or mimic perp function are useful in treatment of such blistering diseases. In another embodiment, agents that inhibit perp function are useful in treating and preventing cancer.