发明名称 |
SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS |
摘要 |
The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from aminoquinoline and aminoquinazoline compounds of Formula (I') : where R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, B, Z, Q, p, q and X are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3. |
申请公布号 |
WO2006135636(A2) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2006US22142 |
申请日期 |
2006.06.07 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;BAUMANN, CHRISTIAN, ANDREW;GAUL, MICHAEL, DAVID |
发明人 |
BAUMANN, CHRISTIAN, ANDREW;GAUL, MICHAEL, DAVID |
分类号 |
A61K45/06;A61P35/00 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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