发明名称 |
A NOVEL PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE GLIMEPIRIDE |
摘要 |
<p>The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HC1 and 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide(I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride Form I (I), having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.</p> |
申请公布号 |
WO2006103690(A1) |
申请公布日期 |
2006.10.05 |
申请号 |
WO2005IN00164 |
申请日期 |
2005.05.18 |
申请人 |
USV LIMITED |
发明人 |
TARUR, VENKATASUBRAMANIAN, RADHAKRISHNAN;KADAM, SURESH, MAHADEV;NAIK, SANJAY, JANARDHAN;GAVHANE, SACHIN, BABAN |
分类号 |
C07D207/38;A61K31/4015;A61P3/10 |
主分类号 |
C07D207/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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