发明名称 |
COMPOSITIONS CONTAINING CHEMICALLY MODIFIED SMALL MOLECULES AND METHODS UTILIZING THE SAME |
摘要 |
<p>The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.</p> |
申请公布号 |
IL176317(D0) |
申请公布日期 |
2006.10.05 |
申请号 |
IL20060176317 |
申请日期 |
2006.06.15 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
|
分类号 |
A61K;A61K31/765;A61K31/785;A61K47/48;C08G65/08 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|