STABLE PHARMACEUTICAL COMPOSITIONS OF PLATINUM (II) ANTITUMOUR AGENTS

摘要

A pharmaceutical composition comprising a platinum (II) complex compound in an aqueous solvent. The pharmaceutical composition is prepared by the essential steps of: (i) adding a platinum (II) complex compound to an oxygen enriched aqueous solvent to obtain a solution; (ii) Sterilizing the solution (iii) Filling the sterilized solution of step (ii) into suitable containers; and (iv) Sealing the containers. The oxygen enriched aqueous solvent is obtained by purging or bubbling of a gas into an aqueous solvent for 30 to 150 minutes. A device for for preparing the pharmaceutical composition is illustrated in Fig.-1. The composition is used for treatment of a human or an animal cancerous disease bay the administration of pharmaceutical compositions of platinum (II) complex compounds as per the claim 1, to the human or animal in need of said treatment.