摘要 |
An emulsion comprising: (a) amitriptyline, (b) ketamine, (c) a lipophilic component, (d) water, or (e) a surfactant, wherein the emulsion is an oil in water emulsion and further comprises a lipophilic intradermal penetration enhancer selected from the group consisting of isopropyl myristate, glycerol monolaurate, glycerol monooleate, glycerol monolinoleate, isopropyl isostearate, isopropyl linoleate, isopropyl myristate/fatty acid monoglyceride combination, isopropyl myristate/ethanol/l-lactic acid combination, isopropyl palmitate, methyl acetate, methyl caprate and methyl laurate. The emulsion is used for the manufacture of topically-applied medicaments for treating pain in a mammal.
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