REVASCULARIZATION OF ISCHEMIC RETINAL TISSUE AND SCREENING METHOD THEREFOR
摘要
The present invention provides a treatment method for promoting beneficial physiological revascularization of ischemic retinal tissue. The method comprises administering to a mammal suffering from a retinal vascular ischemia a therapeutically effective amount of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS), thereby simultaneously inhibiting pathological neovascularization while promoting beneficial physiological revascularization of damaged areas of the retina. In a preferred embodiment, the angiostatic fragment of TrpRS is T2-TrpRS or T2-TrpRS-GD. Preferably, the mammal is a human patient suffering from retinal ischemia. A screening method for identifying and evaluating therapeutic agents for treating retinal neovascular diseases is also disclosed.
申请公布号
WO2006091729(A2)
申请公布日期
2006.08.31
申请号
WO2006US06402
申请日期
2006.02.24
申请人
THE SCRIPPS RESEARCH INSTITUTE;FRIEDLANDER, MARTIN;BANIN, EYAL;AGUILAR, EDITH