<p>Described herein are methods of producing a recombinant protein. The methods can include providing a host cell comprising a recombinant nucleic acid construct, wherein said recombinant nucleic acid construct encodes a recombinant protein and contacting the host cell with a first compound to which the host cell is sensitive. The methods can also include harvesting the host cells and recombinant protein from said host cell. The methods can be practiced with in vitro systems as well. Also described are systems and kits related to the methods. The methods systems and kits can be used to produce soluble recombinant protein and to increase the level of a recombinant protein relative to cellular protein in a host cell</p>
