发明名称 |
METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF RESVERATROL OR AN OLIGOMERIC OR GLYCOSIDICALLY-BOUND DERIVATIVE THEREOF |
摘要 |
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4- hydroxylase (C4H) produces 4-coumaric acid from said trans- cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4- coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4- coumaroyl CoA, or in which L-phenylalanine- or tyrosine- ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4- coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae. |
申请公布号 |
WO2006089898(A1) |
申请公布日期 |
2006.08.31 |
申请号 |
WO2006EP60154 |
申请日期 |
2006.02.21 |
申请人 |
FLUXOME SCIENCES A/S;KATZ, MICHAEL;SMITS, HANS PETER;FOERSTER, JOCHEN;NIELSEN, JENS BREDAL |
发明人 |
KATZ, MICHAEL;SMITS, HANS PETER;FOERSTER, JOCHEN;NIELSEN, JENS BREDAL |
分类号 |
C12N9/00;C12N9/02;C12N9/10;C12N9/88;C12N15/52;C12P7/22;C12P7/42 |
主分类号 |
C12N9/00 |
代理机构 |
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代理人 |
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地址 |
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