CYTOKINE INHIBITORS AND THEIR USE IN THERAPY

摘要

The present invention relates to low molecular weight compounds and compositions thereof, useful as cytokine inhibitors, and their preparation. The invention further relates to methods of prevention and treatment of cytokine-mediated disorders, in particular inflammatory disorders, pain and cancer. The invention also relates to pharmaceutical compositions and dosing regimens. In particular, the invention relates to the use of cytokine inhibitors, optionally in conjunction with other therapies, for cancer, more particularly glioma, glioblastoma, osteosarcoma and bone metastases. Additionally, the present invention relates to methods of treating, modifying and managing pain, more particularly neuropathic pain, which comprise the administration of a cytokine inhibitor alone or in combination with known therapeutics.