PHENYL-PIPERAZIN METHANONE DERIVATIVES

摘要

The present invention relates to compounds of the general formula (I) wherein R<SUP>1</SUP> is the group (A) or (B) or (C) or (D); R<SUP>2</SUP> is a non aromatic heterocycle, or is OR' or N(R")<SUB>2</SUB>; R' is lower alkyl, lower alkyl substituted by halogen or -(CH<SUB>2</SUB>)<SUB>n</SUB>-cycloalkyl; R" is lower alkyl; R<SUP>3</SUP> is NO<SUB>2</SUB>, CN or SO<SUB>2</SUB>R'; R<SUP>4 </SUP>is hydrogen, hydroxy, halogen, NO<SUB>2</SUB>, lower alkyl, lower alkyl, substituted by halogen, lower alkoxy, SO<SUB>2</SUB>R' or C(O)OR"; R<SUP>5</SUP>/R<SUP>6</SUP>/R<SUP>7</SUP> are hydrogen, halogen, lower alkyl or lower alkyl, substituted by halogen; X<SUP>1</SUP>/X<SUP>1'</SUP> are CH or N, with the proviso that X<SUP>1</SUP>/X<SUP>1'</SUP> are not simultaneously CH; X<SUP>2</SUP> is O, S, NH or N(lower alkyl); n is 0, l or 2; and to pharmaceutically active acid addition salts and to their use in the treatment of neurological and neuropsychiatric disorders.