发明名称 NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY
摘要 <p>There are disclosed novel compounds of formula (I) wherein R<SUP>1</SUP>, R<SUP>12</SUP>, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.</p>
申请公布号 WO2006062465(A1) 申请公布日期 2006.06.15
申请号 WO2005SE01835 申请日期 2005.12.05
申请人 ASTRAZENECA AB;BOEGEVIG, ANDERS;LO-ALFREDSSON, YVONNE;PIVONKA, DONALD;TIDEN, ANNA-KARIN 发明人 BOEGEVIG, ANDERS;LO-ALFREDSSON, YVONNE;PIVONKA, DONALD;TIDEN, ANNA-KARIN
分类号 C07D487/04;A61K31/519;A61P9/10 主分类号 C07D487/04
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