| 发明名称 |
HUMAN PAPILLOMA VIRUS INHIBITION BY HAIRPIN RIBOZYME |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a hairpin ribozyme usable in cleaving an RNA transcribed from a human papilloma virus (HPV)-derived gene in the RNA's E6 gene domain. <P>SOLUTION: The hairpin ribozyme including a synthetic ribozyme, i.e. a hairpin portion, binding sites for binding to HPV after viral base 419 or 434, respectively, and cleavage sites for cleaving HPV virus, is provided. A method for detecting virus in tissues based on PCR amplification is also provided. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
| 申请公布号 |
JP2006149387(A) |
申请公布日期 |
2006.06.15 |
| 申请号 |
JP20050346709 |
申请日期 |
2005.11.30 |
| 申请人 |
GOVERNMENT OF THE US OF AMERICA REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES;NORTHERN ILLINOIS UNIV |
发明人 |
HAMPEL ARNOLD;DIPAOLO JOSEPH;SIWKOWSKI ANDREW |
| 分类号 |
C12N15/09;A61K31/282;A61K31/70;A61K35/12;A61K38/00;A61K38/43;A61K45/00;A61K48/00;A61P31/12;A61P35/00;C12N5/00;C12N5/10;C12N9/00;C12N15/113;C12Q1/68;C12Q1/70;C12R1/91 |
主分类号 |
C12N15/09 |
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