发明名称 |
USE OF TRIS(HYDROXYMETHYL) AMINOMETHANE FOR THE STABILIZATION OF PEPTIDES, POLYPEPTIDES AND PROTEINS |
摘要 |
The present invention is directed to a method for reducing the onset or incidence of gelation/fibrillation/aggregation during the up- and down-stream processing and purification of peptides, polypeptides and proteins analogs and/or derivatives thereof, including Glucagon-Like Peptides (GLPs). More particularly, the present invention relates to methods of processing and purifying such peptides, polypeptides and proteins in the presence of tris(hydroxymethyl)aminomethane. |
申请公布号 |
WO2006024631(A3) |
申请公布日期 |
2006.06.15 |
申请号 |
WO2005EP54209 |
申请日期 |
2005.08.26 |
申请人 |
NOVO NORDISK A/S;CHRISTIANSEN, INGUN;STABY, ARNE |
发明人 |
CHRISTIANSEN, INGUN;STABY, ARNE |
分类号 |
C07K1/00 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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