摘要 |
<p num="1"><br/><br/><br/>Compositions, methods and kits are provided that are useful, for example, for <br/>determining activities of multiple cis-regulatory sequences, such as promoters <br/>and enhancers, and/or multiple trans-acting factors, such as transcription <br/>factors, in a cell. In particular, in certain embodiments, compositions are <br/>provided comprising a population of polynucleotide reporter transcription <br/>units (RTUs) in which each RTU comprises a reporter sequence, a processing tag <br/>located in the reporter sequence; and a cis-regulatory element operably linked <br/>to the reporter sequence, wherein the reporter sequences between any two RTUs <br/>in the population, outside of the processing tags, are substantially identical <br/>and wherein the positions of the processing tags within the reporter sequences <br/>distinguish between any two RTUs differing, for example, in their cis-<br/>regulatory elements. The compositions, methods and kits can further be used, <br/>for example, to identify a cell type or disease state, for example, in a <br/>biological organism.<br/>
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