发明名称 |
SENSOR UND METHODE ZUR MESSUNG DER FLÄCHENDICHTE VON MAGNETISCHEN NANOPARTIKELN AUF EINEM MIKROARRAY |
摘要 |
<p>The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles ( 15 ) being directly or indirectly coupled to the target sample ( 11 ), is described. The magnetoresistive sensor device comprises a substrate ( 3 ) having attached thereto binding sites ( 9 ) able to selectively bind target sample ( 11 ), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles ( 15 ) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements ( 17, 19 ), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles ( 15 ). A corresponding method is described as well.</p> |
申请公布号 |
AT326697(T) |
申请公布日期 |
2006.06.15 |
申请号 |
AT20020790607T |
申请日期 |
2002.12.17 |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N.V. |
发明人 |
COEHOORN, REINDER;PRINS, MENNO, W., J. |
分类号 |
A61B5/026;A61B5/20;B01J19/00;C12M1/00;C12Q1/68;G01N15/06;G01N27/72;G01N33/543;G01N37/00;G01R33/09;G01R33/12;H01L43/08;(IPC1-7):G01N33/543 |
主分类号 |
A61B5/026 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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