发明名称 |
COILED-COIL FUSION PROTEINS COMPRISING CELL RECEPTOR DOMAINS |
摘要 |
<p>Fusion proteins and coiled-coil induced dimers prepared from both the ectodomains and the kinase domains are disclosed. The receptor domains when presented in the form of a homodimer or heterodimer by virtue of the coiled-coil tag have enhanced ligand binding activity or enhanced kinase activity. The kinetics of binding and the antagonistic potencies of the ectodomain dimers, and their use to alter or inhibit signaling is described. Application of the ectodomain and kinase domain dimers in assays for selecting compounds capable of inhibiting ligand binding and kinase activity, respectively, is described.</p> |
申请公布号 |
EP1668133(A1) |
申请公布日期 |
2006.06.14 |
申请号 |
EP20040761779 |
申请日期 |
2004.09.02 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
DE CRESCENZO, GREGORY;O'CONNOR, MAUREEN, D.;PAUL-ROC, BEATRICE;ZWAAGSTRA, JOHN;BANVILLE, MYRIAM;JARAMILLO, MARIA |
分类号 |
C12N15/62;A61K38/00;C07K14/71;G01N33/53;(IPC1-7):C12N15/62 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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地址 |
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