| 发明名称 |
DETECTION OF HISTONE MODIFICATION IN CELL-FREE NUCLEOSOMES |
| 摘要 |
<p>This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.</p> |
| 申请公布号 |
EP1668368(A1) |
申请公布日期 |
2006.06.14 |
| 申请号 |
EP20040768123 |
申请日期 |
2004.08.18 |
| 申请人 |
CHROMA THERAPEUTICS LIMITED |
发明人 |
BAWDEN, LINDSAY JANE;BONE, ELIZABETH ANN;DRUMMOND, ALAN HASTINGS;NEEDHAM, LINDSEY ANN |
| 分类号 |
G01N33/564;G01N33/574;G01N33/68;(IPC1-7):G01N33/574 |
主分类号 |
G01N33/564 |
| 代理机构 |
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