发明名称 |
LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS |
摘要 |
A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutra l in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.
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申请公布号 |
CA2553426(A1) |
申请公布日期 |
2005.08.04 |
申请号 |
CA20052553426 |
申请日期 |
2005.01.13 |
申请人 |
ALZA CORPORATION |
发明人 |
ZALIPSKY, SAMUEL;ZHANG, WEIMING;HUANG, SHI KUN |
分类号 |
A61K47/00;A61K9/127;A61K47/48;A61K48/00 |
主分类号 |
A61K47/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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