DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISORDERS, INVOLVING THE MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) GENE

摘要

This invention relates to methods for diagnosing a neurodegenerative disorder or for determining the predisposition of a subject to such a neurodegenerative disorder. In particular, the methods comprise analysing a bilogical sample from a subject for the presence of a polymorphism in a regulatory region or exon 1 of the MAPT gene. The invention also relates to polynucleotide probes and diagnostic kits and to use of these probes and kits in the methods of screening for neurodegenerative disorders. The invention also relates to methods of treatment of neurodegenerative disorders and to methods of screening for therapeutic compounds useful in such methods of treatment.