发明名称 |
Cyclic amine BACE-1 inhibitors having a benzamide substituent |
摘要 |
<p>Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is—C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with aβ-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.</p> |
申请公布号 |
AU2004265298(A1) |
申请公布日期 |
2005.02.24 |
申请号 |
AU20040265298 |
申请日期 |
2004.08.04 |
申请人 |
PHARMACOPEIA DRUG DISCOVERY, INC.;SCHERING CORPORATION |
发明人 |
THUY X. H. LE;TAO GUO;YING HUANG;JARED N. CUMMING;JEFFREY F. LOWRIE;YAN XIA;COREY STRICKLAND;SAMUEL CHACKALAMANNIL;ANDREW STAMFORD;YUSHENG WU;JOHANNES H. VOIGT;DOUGLAS W. HOBBS;SURESH D. BABU;KURT W. SAIONZ;ULRICH ISERLOH |
分类号 |
C07D403/14;A61K31/40;A61K31/47;A61K31/495;A61K31/5355;A61K31/55;A61K31/553;A61K31/554;A61K31/675;A61K33/42;C07D207/09;C07D211/26;C07D217/18;C07D241/04;C07D243/08;C07D401/06;C07D403/12;C07D413/06;C07F9/38 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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