| 摘要 |
PURPOSE:To obtain a remedy for gastric ulcer containing a bacterium cell ingredient of Streptococcus haemolyticus having reduced toxicity as an active ingredient and exhibiting excellent action in cases difficult to treat especially for aged patients by conventional oral medication. CONSTITUTION:Living bacteria cells are suspended in a medium containing penicillin G, cephalosporim C or cycloserine, kept at 30-38 deg.C and then heat- treated at 40-50 deg.C to reduce the toxicity of bacteria cells. The resultant Strepto coccus haemolyticus (e.g. PCB-45 or OK-432) is used and formulated into an oral medicine or injection drug, preferably in locally administrating form to gastric mucosa to provide the aimed remedy. When the remedy is locally admin istrated to gastric mucosa, the dose is 0.01-1mg per adult/day based on the dried bacterium cell. The Streptococcus haemolyticus is A group Streptococcus pyogenes Su strain (e.g. ATCC 21060). |
