.alpha.-CHLORINATED CARBONATES, THEIR METHOD OF MANUFACTUREAND APPLICATION IN THE PROTECTION OF THE AMINE FUNCTIONS OF AMINO ACIDS

摘要

New .alpha.-chlorinated carbonates, their method of manufacture and application in the protection of the amine functions of amino acids The invention relates to new .alpha.-chlorinated carbonates characterized in that their formula is: in which X is a fluorine, chlorine or bromine atom and R1 is different from the group and represents: - a substituted or non-substituted,saturated or unsaturated, aliphatic, araliphatic, primary, secondary, tertiary or cycloaliphatic radical. These .alpha.-chlorinated carbonates are prepared by the action of a compound of formula R1OH on a chloroformate of formula: in a solvent medium in the presence of an acid scavenger which is added after the two preceding compounds. They are used to block the amine function of amino acids. The .alpha.-chlorinated carbonate and amino acid are reacted in a solvent medium at a temperature of -5.degree. to 100.degree.C in the presence of an acid scavenger. Blocked amines are very useful in peptide synthesis.