| 摘要 |
Phenoxyethylamine derivatives represented by the general formula (I): <CHEM> wherein R1 and R5 represent lower-alkyl, R2 and R3, which may be the same or different, each represents hydrogen or lower-alkyl, or <CHEM> represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent alpha 1-blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed. |
