发明名称 |
TRANSFERRIN RECEPTOR SPECIFIC ANTIBODY-NEUROPHARMACEUTICAL AGENT CONJUGATES |
摘要 |
2066244 9103259 PCTABS00003 The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical agent and methods for treating hosts afflicted with a disease associated with a neurological disorder.
|
申请公布号 |
CA2066244(A1) |
申请公布日期 |
1991.03.08 |
申请号 |
CA19902066244 |
申请日期 |
1990.09.07 |
申请人 |
ALKERMES, INC. |
发明人 |
FRIDEN, PHILLIP |
分类号 |
A61K39/395;A61K38/00;A61K47/48;A61K51/10;C07K14/475;C07K14/48;C07K14/79;C12N9/08;(IPC1-7):A61K47/48 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|