| 摘要 |
PURPOSE: To obtain a porous, unitary freeze-dried pharmaceutical form consisting of an inclusion compound comprising one or more active substances and cyclodextrin, a diluent and/or a binder, and optionally one or more additives, capable of being easily administered, and exhibiting sufficient biological utility. CONSTITUTION: This porous pharmaceutical form is obtained by preparing a paste comprising (A) an inclusion compound comprising one or more kinds of active ingredients, cyclodextrin (preferablyβ-cyclodextrin), and optionally an additive facilitating inclusion (e.g. a buffering agent, an electrolyte), (B) a diluent, such as mannitol, lactose and/or a binder such as gelatin, an alginic salt, and (C) optionally one or more additives such as a flavor, a disintegrator, a coloring agent and/or a stabilizer, dividing the prepared paste into units each having a prescribed shape and a volume, lyophilizing the units, and optionally further dividing the lyophilized products. The form is especially effective for active substances which are insoluble or unstable or which have nonacceptable tastes or insufficient biological utilities.
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