发明名称 |
METHOD FOR PRODUCING BONE MARROW GROWTH CELL FACTORS |
摘要 |
A process is provided for obtaining one or more bone marrow cell growth factors having granulocyte/macrophage progenitor cell colony stimulating activity, said process comprising: (a) adding to the culture medium of an in vitro, established bone marrow culture a growth factor-stimulating amount of a dithiocarbamate; (b) separating the said dithiocarbamate from the in vitro treated bone marrow culture, adding fresh culture medium to said in vitro treated bone marrow culture, and permitting the concentration of said growth factor or factors to increase in said fresh culture medium; and (c) isolating said growth factor or factors from said fresh culture medium. |
申请公布号 |
WO9105571(A1) |
申请公布日期 |
1991.05.02 |
申请号 |
WO1990US05686 |
申请日期 |
1990.10.04 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
BORCH, RICHARD, F.;SCHMALBACH, THERESE, K. |
分类号 |
A61K38/00;C07K14/53;C12N5/077 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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