| 摘要 |
A method for the immobilization of an organic thiol compound, HS-R, in which R is an organic residue, to a water-insoluble polymer of non-polypeptide structure exhibiting a disulfide (-S-S-) group directly bound to a saturated carbon atom at each of its sulphur atoms, which comprising contacting the polymer with an oxidation agent in such an amount and of such a kind that it is capable of transforming the disulfide group (-S-S-) to an oxidized disulfide group capable of reacting with thiol groups, whereupon the polymer obtained exhibiting one or more oxidized disulfide groups is contacted with the organic thiol compound HS-R under conditions allowing reaction to the formation of one -S-S-R group and one -SOn(H) group per disulfide oxide group that undergoes the reaction, where n is 1 or 2. |
