| 摘要 |
The present invention relates to modified forms of IL-1 beta with altered IL-1 activity. The modified IL-1 beta is the result of mutations which affect amino acids in the beta barrel portion of the IL-1 beta structural formula. The invention also relates to expression systems that will produce the modified IL-1 beta polypeptides, and methods of treating susceptible diseases with the modified IL-1 beta polypeptides. |
