TRANSDERMAL ESTRADIOL DELIVERY SYSTEM

摘要

The invention is represented by a transdermal medicated patch for the extended release of 17 beta -estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1 % to 5 % (w/w) 17 beta -estradiol, and a protective liner which is removed before use. The matrix is formed of pressure sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical polymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5 % (w/w) of other substances may be added.