4-AMINO-3-ACYL QUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF GASTRIC ACID SECRETION

摘要

2125681 9312090 PCTABS00022 A compound of formula (I), wherein R1 denotes hydrogen, hydroxyl (OH), halogen or C1-4alkyl, R2 denotes hydrogen or C1-4alkyl, R3 denotes C1-4alkyl, A denotes methylene(-CH2-), ethylene (-CH2CH2-), ethylidene ¢-CH(CH3)-!, trimethylene (-CH2CH2CH2-), oxyethylene (-O-CH2CH2-) or oxytrimethylene (-O-CH2CH2CH2-), X denotes C1-6alkylene or C2-4alkenylene and Y denotes hydroxyl (OH) or amino (NH2), or a salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.