ENZYMATICALLY-PRODUCED DIMERIC IL-2 AND A NERVE-DERIVED TRANSGLUTAMINASE ENYZME FOR ITS PREPARATION

摘要

The invention provides a new nerve-derived transglutaminase enzyme that converts immune-derived IL-2 to dimeric IL-2 having oligodendxocyte cytotoxic activity. Both the nervederived transglutaminase and the dimeric mammalian, e.g. human, IL-2, are for use as active ingredients in pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals.