发明名称 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
摘要 The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
申请公布号 US7576089(B2) 申请公布日期 2009.08.18
申请号 US20040014322 申请日期 2004.12.16
申请人 INCYTE CORPORATION 发明人 XUE CHU-BIAO;METCALF BRIAN W.;HAN AMY QI;ROBINSON DARIUS J.;ZHENG CHANGSHENG;WANG ANLAI;ZHANG YINGXIN
分类号 C07D403/14;A61K31/4025;A61K31/427;A61K31/44;A61K31/4439;A61K31/506;C07D401/12;C07D401/14;C07D417/02 主分类号 C07D403/14
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