发明名称 |
Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption |
摘要 |
Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
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申请公布号 |
US7576067(B2) |
申请公布日期 |
2009.08.18 |
申请号 |
US20040000814 |
申请日期 |
2004.12.01 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
WEINBACH SUSAN;TILLMAN LLOYD G.;GEARY RICHARD S.;HARDEE GREGORY E. |
分类号 |
A61K31/70;A61K47/12;A61K9/20;A61K9/22;A61K9/24;A61K9/26;A61K9/28;A61K9/42;A61K9/48;A61K9/52;A61K9/54;A61K9/66;A61K31/20;A61K31/7088;A61K38/00;A61K39/00;A61K39/395;A61K47/04;A61K47/08;A61K47/14;A61K47/16;A61K47/18;A61K47/22;A61K47/26;A61K47/28;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61K48/00;A61P1/04;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C07H21/04 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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