PRODUCTION OF ULTRAPURE BISMUTH-213 FOR USE IN THERAPEUTIC NUCLEAR MEDICINE

摘要

A multicolumn selectivity inversion generator has been developed in which bismuth-213 is selectively extracted from an HC1 solution of the actinium-22 5 parent (and its radiogenic descendents) by a primary separation column containing a separation medium containing a neutral oxygenated organophosphorus extractant. After rinsing with dilute HC1, the bismuth-213 is stripped with a buffered NaC1 solution. The stripped solution is passed through a cation-exchange resin guard column that retains the actinium-225 a nd radium-225 contaminants while the bismuth-213 elutes. This generator method minimizes the unpredictable effects of radiation damage to the support material and permits the reliable production of bismuth-213 of high chemical and radionuclidic purity.