发明名称 |
NON-MALIGNANT DISEASE TREATMENT WITH RAS ANTAGONISTS |
摘要 |
Disclosed is a method for inhibiting Ras-induced or mediated proliferation of cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The inventio n is particularly applicable to diseases characterized by a proliferation of T- cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells includ e cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans - trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.
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申请公布号 |
CA2377254(C) |
申请公布日期 |
2009.08.18 |
申请号 |
CA20002377254 |
申请日期 |
2000.06.19 |
申请人 |
THYREOS CORPORATION;RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH &INDUSTRIAL DEVELOPMENT |
发明人 |
BRUCK, RAFAEL;CHAPMAN, JOAB;REIF, SHIMON;BROWNSTEIN, MICHAEL;KLOOG, YOEL |
分类号 |
A61K31/60;C07D213/70;A61K31/00;A61K31/18;A61K31/185;A61K31/192;A61K31/196;A61K31/21;A61K31/235;A61K31/44;A61K31/455;A61K31/465;A61K31/606;A61K45/00;A61P1/16;A61P25/00;A61P37/00 |
主分类号 |
A61K31/60 |
代理机构 |
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