发明名称 |
CAMPTOTHECIN DERIVATIVES HAVING ANTITUMOR ACTIVITY |
摘要 |
Camptothecin derivatives of camptothecin of formula (I), wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
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申请公布号 |
CA2362760(C) |
申请公布日期 |
2009.08.18 |
申请号 |
CA20002362760 |
申请日期 |
2000.03.08 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.;ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI |
发明人 |
PENCO, SERGIO;CARMINATI, PAOLO;ZUNINO, FRANCO;MERLINI, LUCIO |
分类号 |
C07D491/22;A61K31/435;A61K31/4745;A61P31/12;A61P33/06;A61P35/00;C07D209/00;C07D221/00;C07D311/00 |
主分类号 |
C07D491/22 |
代理机构 |
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地址 |
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