Use of marker sequences for the diagnosis of rheumatoid arthritis, where the marker sequences of a complementary DNA (cDNA) from the specific sequence is determined in a patient

摘要

Use of marker sequences for the diagnosis of rheumatoid arthritis, is claimed, where at least a marker sequence of a complementary DNA (cDNA) from the SEQ ID NO. 1-488 (not defined) or a protein obtained from the sequence, a partial sequence or a fragment of the sequence, is determined in a patient. Independent claims are included for: (1) diagnosing rheumatoid arthritis comprising introducing the marker sequences on a solid carrier and contacting with body fluids or tissue extracts of a patient and determining the interaction of the body fluids or tissue extracts with the marker sequences; (2) a procedure for the stratification, preferably for risk stratification or for the therapy control of a patient with rheumatoid arthritis, comprising determining the marker sequences in a patient; (3) an arrangement of marker sequences; (4) an assay, protein biochip consisting of the arrangement, where the marker sequences are applied on a solid carrier; (5) a diagnostic agent for the diagnosis of rheumatoid arthritis comprising the marker sequence; and (6) a target for the treatment and therapy of rheumatoid arthritis from the marker sequence.