INTEGRATED MAGNETIC FIELD GENERATION AND DETECTION PLATFORM

摘要

An integrated magnetic field generation and detection platform is described that is capable of manipulating and detecting individual magnetic particles, such as spherical super-paramagnetic beads, and providing biosensing functionality. The platform is implemented in an integrated circuit, a portion of the surface of which is functionalized with one or more biochemical agents that binds tightly (i.e., specifically) with a target analyte. The magnetic beads are similarly functionalized with one or more biochemical agents that bind specifically with the target analyte. When a sample is introduced, magnetic beads that specifically bind to the integrated circuit can be separated from non-specifically bound beads and detected.